IMIPENEM CILASTATIN

Brand Name & Strength

Tienam® 500 mg

Reconstitution

Reconstitute with 10 ml diluent , repeat with an additional 10 ml of diluent to ensure complete transfer of vial contents.

Further Dilution

Dilute with 100 ml of diluent (max concentration: 5 mg/ml)

Diluent

D5, NS

Administration & Infusion rate

IV infusion

Dose ≥ 750 mg: Administered at over 40 – 60 min

Dose ≤ 500 mg: Administered at over 20 – 30 min

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

-

After dilution

4 hr 24 hr

Remarks

Administer only as slow

IV infusion

. Do not give by direct IV injection.

To slow infusion rate if patient experienced nausea, vomiting, dizziness, or sweating.